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Article

DNA-PKcs chemical inhibition versus genetic mutation: Impact on the junctional repair steps of V(D)J recombination.

Molecular immunology - 1 Apr 2020

Anne Esguerra Z, Watanabe Go, Okitsu Cindy Y, Hsieh Chih-Lin, Lieber Michael R

Abstract excerpt

Spontaneous DNA-PKcs deficiencies in animals result in a severe combined immunodeficiency (SCID) phenotype because DNA-PKcs is required to activate Artemis for V(D)J recombination coding end hairpin opening. The impact on signal joint formation in these spontaneous mutant mammals is variable. Genetically engineered DNA-PKcs null mice and cells from them show a >1,000-fold reduction in coding joint formation and...

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Identifiers

PMID: 32113132
DOI: 10.1016/j.molimm.2020.01.018
PMCID: PMC7184946

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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