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Article

The end-joining reaction in V(D)J recombination.

Seminars in immunology - 1 Jun 1997

Smider V, Chu G

Abstract excerpt

V(D)J recombination consists of a DNA cleavage reaction catalysed by RAG1 and RAG2, followed by an end-joining reaction that utilizes the cell's double-strand break repair machinery. Genes essential for the end-joining reaction include: XRCC4 encoding a protein of unknown enzymatic function; XRCC5 and XRCC6 encoding 86 and 70 kDa subunits of the Ku autoantigen, a DNA end-binding protein that is also the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9200330
DOI: 10.1006/smim.1997.0070

Genes

RAG1
RAG2
XRCC4
XRCC5
XRCC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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The end-joining reaction in V(D)J recombination.PMID 9200330Read ↗

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining PathwaySemantic proximity Read ↗

The DNA‐dependent protein kinase: the director at the endSemantic proximity Read ↗

Repair of double-strand breaks by end joining.Semantic proximity Read ↗

The spatial organization of non-homologous end joining: From bridging to end joiningSemantic proximity Read ↗

Failure of hairpin-ended and nicked DNA To activate DNA-dependent protein kinase: implications for V(D)J recombination.Semantic proximity Read ↗

Investigating the regulation of DNA non-homologous end-joining through Ku70/80 interacting factorsSemantic proximity Read ↗

Repair of DNA double-strand breaks by mammalian alternative end-joining pathwaysSemantic proximity Read ↗

Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination.Semantic proximity Read ↗

How to fix DNA breaks: new insights into the mechanism of non-homologous end joiningSemantic proximity Read ↗

DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK.Semantic proximity Read ↗

Non‐homologous end joining: Common interaction sites and exchange of multiple factors in the DNA repair processSemantic proximity Read ↗

The pendulum of the Ku-Ku clockSemantic proximity Read ↗

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