Article
DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK.
Trends in biochemical sciences - 1 Oct 1995
Jackson S P, Jeggo P A
Abstract excerpt
Two processes involving DNA double-strand breaks (DSBs) are the repair of DNA damage induced by ionizing radiation, and V(D)J recombination, the genomic rearrangement that creates antigen-receptor diversity in vertebrates. Recent evidence indicates that DNA-dependent protein kinase (DNA-PK), whic...
Topics
- Animals
- DNA
- DNA Damage
- DNA Repair
- DNA-Activated Protein Kinase
- DNA-Binding Proteins
- Gene Rearrangement
- Genetic Complementation Test
- Mammals
- Models, Genetic
- Mutation
- Protein Serine-Threonine Kinases