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Article

DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK.

Trends in biochemical sciences - 1 Oct 1995

Jackson S P, Jeggo P A

Abstract excerpt

Two processes involving DNA double-strand breaks (DSBs) are the repair of DNA damage induced by ionizing radiation, and V(D)J recombination, the genomic rearrangement that creates antigen-receptor diversity in vertebrates. Recent evidence indicates that DNA-dependent protein kinase (DNA-PK), which is activated by DNA ends, is a central component of both the DNA DSB repair and V(D)J recombination machineries.

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Source

Identifiers

PMID: 8533154
DOI: 10.1016/s0968-0004(00)89090-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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