Article
The catalytic subunit of DNA-protein kinase (DNA-PKcs) is not required for Ig class-switch recombination.
Proceedings of the National Academy of Sciences of the United States of America - 20 Feb 2007
Kiefer Kerstin, Oshinsky Jennifer, Kim Jiyoon, Nakajima Pamela B, Bosma Gayle C, Bosma Melvin J
Abstract excerpt
The joining of DNA ends during Ig class-switch recombination (CSR) is thought to involve the same nonhomologous end-joining pathway as used in V(D)J recombination. However, we reported earlier that CSR can readily occur in Ig transgenic SCID mice lacking DNA-dependent protein kinase (DNA-PK) activity, a critical enzymatic activity for V(D)J recombination. We were thus led to question whether the catalytic subunit...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.