Article
Different classes of coactivators recognize distinct but overlapping binding sites on the estrogen receptor ligand binding domain.
The Journal of biological chemistry - 23 Oct 1998
Eng F C, Barsalou A, Akutsu N, Mercier I, Zechel C, Mader S, White J H
Abstract excerpt
We have analyzed interaction of coactivators with the wild-type estrogen receptor alpha (ER), HEG0, and a mutant, L536P-HEG0, which is constitutively active in several transiently transfected cells and a HeLa line that stably propagates an estrogen-sensitive reporter gene. Different classes of co...
Topics
- Adaptor Proteins, Signal Transducing
- Animals
- Binding Sites
- Binding, Competitive
- Breast Neoplasms
- COS Cells
- Estrogens
- Female
- HeLa Cells
- Histone Acetyltransferases
- Humans
- Ligands
- Mutation
- Nuclear Proteins
- Nuclear Receptor Coactivator 1
- Nuclear Receptor Interacting Protein 1
- Ovarian Neoplasms
- Peptide Fragments