Article
Role of coactivators and corepressors in steroid and nuclear receptor signaling: potential markers of tumor growth and drug sensitivity.
The International journal of biological markers - 1 Jan 2000
Cottone E, Orso F, Biglia N, Sismondi P, De Bortoli M
Abstract excerpt
Nuclear receptors regulate target gene expression in response to steroid and thyroid hormones, retinoids, vitamin D and other ligands. These ligand-dependent transcription factors function by contacting various nuclear cooperating proteins, called coactivators and corepressors, which mediate local chromatin remodeling as well as communication with the basal transcriptional apparatus. Nuclear receptors and their...
Topics
- Biomarkers, Tumor
- Genetic Predisposition to Disease
- Humans
- Receptor Cross-Talk
- Receptors, Cytoplasmic and Nuclear
- Receptors, Steroid
- Repressor Proteins
- Transcription, Genetic
- Transcriptional Activation