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The Transcriptional Coregulator RIP140 Represses E2F1 Activity and Discriminates Breast Cancer Subtypes

22 Apr 2010

Abstract excerpt

PURPOSE: Receptor-interacting protein of 140 kDa (RIP140) is a transcriptional cofactor for nuclear receptors involved in reproduction and energy homeostasis. Our aim was to investigate its role in the regulation of E2F1 activity and target genes both in breast cancer cell lines and in tumor biopsies. EXPERIMENTAL DESIGN: Glutathione S-transferase pull-down assays, coimmunoprecipitation experiments, and chromatin...

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PMID: 20410059
DOI: 10.1158/1078-0432.ccr-09-3153

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