Article
Cooperative activation of gene expression by agonists and antagonists mediated by estrogen receptor heteroligand dimer complexes.
Molecular pharmacology - 1 May 2013
Liu Shuang, Han Sang Jun, Smith Carolyn L
Abstract excerpt
Estrogen receptor (ER) antagonists are generally thought to inhibit estrogen action through competitive inhibition, resulting in receptor binding to antagonist rather than agonist. However, microarray analyses reveal a group of genes for which ER agonist and antagonist cooperatively regulate expression, suggesting additional models of combined agonist/antagonist action must exist. In conjunction with a chimeric...
Topics
- Cell Line, Tumor
- DNA
- Estradiol
- Estrogen Antagonists
- Estrogens
- Fulvestrant
- Gene Expression
- HeLa Cells
- Hep G2 Cells
- Humans
- Indoles
- Ligands
- Mutation
- Promoter Regions, Genetic
- Protein Multimerization