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Article

Altered target gene regulation controlled by estrogen receptor-alpha concentration.

Molecular endocrinology (Baltimore, Md.) - 1 Feb 2006

Fowler Amy M, Solodin Natalia M, Valley Christopher C, Alarid Elaine T

Abstract excerpt

Estrogen receptor-alpha (ERalpha) is a transcriptional activator whose concentration is tightly regulated by the cellular environment. In breast tumors of postmenopausal women, elevated receptor concentrations can be associated with negative clinical outcomes, yet it remains poorly understood how such high levels impact ERalpha function. We previously demonstrated that high nuclear concentrations of ERalpha in...

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Identifiers

PMID: 16179380
DOI: 10.1210/me.2005-0288

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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