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Article

Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1.

Genes & development - 15 Nov 1998

Zwijsen R M, Buckle R S, Hijmans E M, Loomans C J, Bernards R

Abstract excerpt

The estrogen receptor (ER) is an important regulator of growth and differentiation of breast epithelium. Transactivation by ER depends on a leucine-rich motif, which constitutes a ligand-regulated binding site for steroid receptor coactivators (SRCs). Cyclin D1 is frequently amplified in breast cancer and can activate ER through direct binding. We show here that cyclin D1 also interacts in a ligand-independent...

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Identifiers

PMID: 9832502
DOI: 10.1101/gad.12.22.3488
PMCID: PMC317237

Genes

SRC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cyclin E1 and cyclin E2 in ER+ breast cancer: prospects as biomarkers and therapeutic targetsSemantic proximity Read ↗

Estrogen induction of the cyclin D1 promoter: Involvement of a cAMP response-like elementSemantic proximity Read ↗

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