Article
Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1.
Genes & development - 15 Nov 1998
Zwijsen R M, Buckle R S, Hijmans E M, Loomans C J, Bernards R
Abstract excerpt
The estrogen receptor (ER) is an important regulator of growth and differentiation of breast epithelium. Transactivation by ER depends on a leucine-rich motif, which constitutes a ligand-regulated binding site for steroid receptor coactivators (SRCs). Cyclin D1 is frequently amplified in breast c...
Topics
- Animals
- COS Cells
- Cyclin D1
- Gene Expression Regulation, Neoplastic
- Histone Acetyltransferases
- Humans
- Ligands
- Mutation
- Nuclear Proteins
- Nuclear Receptor Coactivator 1
- Protein Binding
- Receptors, Estrogen
- Recombinant Fusion Proteins
- Transcription Factors
- Transcriptional Activation
- Transfection
- Tumor Cells, Cultured