Article
Mechanistic aspects of estrogen receptor activation probed with constitutively active estrogen receptors: correlations with DNA and coregulator interactions and receptor conformational changes.
Molecular endocrinology (Baltimore, Md.) - 1 Aug 1997
Lazennec G, Ediger T R, Petz L N, Nardulli A M, Katzenellenbogen B S
Abstract excerpt
The estrogen receptor (ER) belongs to a large family of nuclear receptors, many of whose members function as ligand-dependent transcriptional activators. The mechanism by which the receptor is converted from an inactive into an activated state is not yet completely understood. To investigate the kind of changes in receptor conformation and interactions that are involved in this activation, we have used the wild...
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