Article
Mechanistic aspects of estrogen receptor activation probed with constitutively active estrogen receptors: correlations with DNA and coregulator interactions and receptor conformational changes.
Molecular endocrinology (Baltimore, Md.) - 1 Aug 1997
Lazennec G, Ediger T R, Petz L N, Nardulli A M, Katzenellenbogen B S
Abstract excerpt
The estrogen receptor (ER) belongs to a large family of nuclear receptors, many of whose members function as ligand-dependent transcriptional activators. The mechanism by which the receptor is converted from an inactive into an activated state is not yet completely understood. To investigate the...
Topics
- Adaptor Proteins, Signal Transducing
- Carrier Proteins
- DNA
- DNA-Binding Proteins
- Electrophoresis
- Estradiol
- Glutathione Transferase
- Histone Acetyltransferases
- Mutation
- Nuclear Proteins
- Nuclear Receptor Coactivator 1
- Nuclear Receptor Interacting Protein 1
- Protein Conformation