Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Estrogen receptor corepressors -- a role in human breast cancer?

1 Dec 2003

Abstract excerpt

Estrogen receptor alpha (ERalpha) has an established role in promoting breast cancer. Transcriptional activation by ERalpha is a complex and multistep process, and it is influenced by coactivator and corepressor proteins that can either positively or negatively modulate ERalpha-mediated transcriptional activity. Corepressors are proposed to provide a counterbalance to the estrogen-induced transactivation, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bioactive Compounds and Antitumor Agents
Share to Cytokine Signaling Pathways and Interactions
Share to Estrogen and related hormone effects

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 14713265
DOI: 10.1677/erc.0.0100517

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Estrogen receptor corepressors -- a role in human breast cancer?PMID 14713265Read ↗

A Negative Coregulator for the Human ERSemantic proximity Read ↗

Role of coactivators and corepressors in steroid and nuclear receptor signaling: potential markers of tumor growth and drug sensitivity.Semantic proximity Read ↗

Decreased BRCA1 confers tamoxifen resistance in breast cancer cells by altering estrogen receptor-coregulator interactions.Semantic proximity Read ↗

Mechanisms of estrogen receptor antagonism toward p53 and its implications in breast cancer therapeutic response and stem cell regulation.Semantic proximity Read ↗

Modulation of estrogen receptor alpha activity and expression during breast cancer progression.Semantic proximity Read ↗

Mechanisms for estrogen receptor expression in human cancerSemantic proximity Read ↗

New perspectives into the biological and clinical relevance of oestrogen receptors in the human breastSemantic proximity Read ↗

The tamoxifen-responsive estrogen receptor alpha mutant D351Y shows reduced tamoxifen-dependent interaction with corepressor complexes.Semantic proximity Read ↗

ER re-expression and re-sensitization to endocrine therapies in ER-negative breast cancers.Semantic proximity Read ↗

The expression and function of estrogen receptor alpha and beta in human breast cancer and its clinical application.Semantic proximity Read ↗

The Estrogen Receptor β-Isoform (ERβ) of the Human Estrogen Receptor Modulates ERα Transcriptional Activity and Is a Key Regulator of the Cellular Response to Estrogens and Antiestrogens1Semantic proximity Read ↗

Estrogen Signaling: A Subtle Balance Between ER and ERSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.