Article
Multimer formation is not essential for nuclear export of human T-cell leukemia virus type 1 Rex trans-activator protein.
Journal of virology - 1 Nov 1998
Heger P, Rosorius O, Koch C, Casari G, Grassmann R, Hauber J
Abstract excerpt
The Rex trans-regulatory protein of human T-cell leukemia virus type 1 (HTLV-1) is required for the nuclear export of incompletely spliced and unspliced viral mRNAs and is therefore essential for virus replication. Rex is a nuclear phosphoprotein that directly binds to its cis-acting Rex response...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Biological Transport, Active
- COS Cells
- Cell Line
- Cell Nucleus
- Fluorescent Antibody Technique, Indirect
- Gene Products, rex
- HeLa Cells
- Human T-lymphotropic virus 1
- Humans
- Leucine Zippers
- Macromolecular Substances
- Molecular Sequence Data
- Mutation
- Protein Conformation
- RNA Splicing