Article
The type I human T-cell leukemia virus (HTLV-I) Rex trans-activator binds directly to the HTLV-I Rex and the type 1 human immunodeficiency virus Rev RNA response elements.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1991
Bogerd H P, Huckaby G L, Ahmed Y F, Hanly S M, Greene W C
Abstract excerpt
The Rex protein of the type I human T-cell leukemia virus (HTLV-I) is essential for the replication of this pathogenic retrovirus and, surprisingly, can also replace the function of the structurally distinct Rev protein of the type 1 human immunodeficiency virus (HIV-1). Rex action requires a 255-nucleotide viral RNA stem-loop structure termed the Rex RNA response element (RexRE) located in the 3' retroviral long...
Topics
- Binding Sites
- Carrier Proteins
- Cloning, Molecular
- Escherichia coli
- Gene Products, rev
- Gene Products, rex
- HIV-1
- Human T-lymphotropic virus 1
- Mutation
- RNA, Viral