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Article

Transdominant repressors for human T-cell leukemia virus type I rex and human immunodeficiency virus type 1 rev function.

Journal of virology - 1 Jan 1991

Böhnlein S, Pirker F P, Hofer L, Zimmermann K, Bachmayer H, Böhnlein E, Hauber J

Abstract excerpt

Human T-cell leukemia virus type I (HTLV-I) encodes a 27-kDa trans-acting gene product (Rex) which is involved in the regulated expression of transcripts coding for the viral structural proteins. We used oligonucleotide-directed mutagenesis to generate a series of mutant HTLV-I rex genes. Transient expression experiments demonstrated that 3 of 28 mutant proteins are functionally inactive on the homologous HTLV-I...

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Identifiers

PMID: 1985219
DOI: 10.1128/JVI.65.1.81-88.1991
PMCID: PMC240491

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Transdominant repressors for human T-cell leukemia virus type I rex and human immunodeficiency virus type 1 rev function.PMID 1985219Read ↗

Dominant-negative mutants are clustered in a domain of the human T-cell leukemia virus type I Rex protein: implications for trans dominance.Semantic proximity Read ↗

The type I human T-cell leukemia virus (HTLV-I) Rex trans-activator binds directly to the HTLV-I Rex and the type 1 human immunodeficiency virus Rev RNA response elements.Semantic proximity Read ↗

Dominant negative mutants of human T-cell leukemia virus type I Rex and human immunodeficiency virus type 1 Rev fail to multimerize in vivo.Semantic proximity Read ↗

Binding of trans-dominant mutant Rev protein of human immunodeficiency virus type 1 to the cis-acting Rev-responsive element does not affect the fate of viral mRNA.Semantic proximity Read ↗

Multimer formation is not essential for nuclear export of human T-cell leukemia virus type 1 Rex trans-activator protein.Semantic proximity Read ↗

Titration of cellular export factors, but not heteromultimerization, is the molecular mechanism of trans-dominant HTLV-1 rex mutants.Semantic proximity Read ↗

Effects of translation initiation factor eIF-5A on the functioning of human T-cell leukemia virus type I Rex and human immunodeficiency virus Rev inhibited trans dominantly by a Rex mutant deficient in RNA binding.Semantic proximity Read ↗

Mutational analysis of bovine leukemia virus Rex: identification of a dominant-negative inhibitor.Semantic proximity Read ↗

Multiple arginine residues within the basic domain of HTLV-I Rex are required for specific RNA binding and function.Semantic proximity Read ↗

Effects of chimeric mutants of human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex on nucleolar targeting signals.Semantic proximity Read ↗

High-resolution mapping of the human T-cell leukemia virus type 1 Rex-binding element by in vitro selection.Semantic proximity Read ↗

Minimal Rev-response element for type 1 human immunodeficiency virus.Semantic proximity Read ↗

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