Article
Dominant-negative mutants are clustered in a domain of the human T-cell leukemia virus type I Rex protein: implications for trans dominance.
Journal of virology - 1 Jul 1992
Weichselbraun I, Berger J, Dobrovnik M, Bogerd H, Grassmann R, Greene W C, Hauber J, Böhnlein E
Abstract excerpt
The 27-kDa Rex trans-acting protein appears to be essential for replication of human T-cell leukemia virus type I. Mutations introduced outside of the Rex RNA-binding domain-nucleolar localization signal display either wild-type activity or, conversely, yield dominant-negative proteins. We genera...
Topics
- Amino Acid Sequence
- Base Sequence
- Cloning, Molecular
- DNA, Viral
- Gene Products, rex
- Genes, Dominant
- Human T-lymphotropic virus 1
- Molecular Sequence Data
- Mutation
- Sequence Alignment