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Article

HIV-1 Rev oligomerization is not obligatory in the presence of an extra basic domain.

Retrovirology - 10 Jun 2005

Furnes Clemens, Arnesen Thomas, Askjaer Peter, Kjems Jørgen, Szilvay Anne Marie

Abstract excerpt

BACKGROUND: The HIV-1 Rev regulatory protein binds as an oligomeric complex to viral RNA mediating nuclear export of incompletely spliced and non-spliced viral mRNAs encoding the viral structural proteins. However, the biological significance of the obligatory complex formation of Rev upon the viral RNA is unclear. RESULTS: The activity of various fusion proteins based on the negative oligomerization-defect Rev...

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Identifiers

PMID: 15949040
DOI: 10.1186/1742-4690-2-39
PMCID: PMC1180471

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