Article
Chloroquine modulation of specific metabolizing enzymes activities: investigation with selective five drug cocktail.
British journal of clinical pharmacology - 1 Sept 1998
Adedoyin A, Frye R F, Mauro K, Branch R A
Abstract excerpt
AIMS: The aim of this study was to investigate whether chloroquine can inhibit drug metabolism in humans, if such inhibition is general or selective for certain enzymes and evaluate the potential for and clinical significance of any drug-drug interactions when chloroquine is co-administered with other drugs. METHODS: The study was conducted in fourteen normal non-smoking healthy male volunteers using a cocktail...
Topics
- Adult
- Analysis of Variance
- Antimalarials
- Caffeine
- Chloroquine
- Chlorzoxazone
- Cytochrome P-450 Enzyme Inhibitors
- Cytochrome P-450 Enzyme System
- Dapsone
- Debrisoquin
- Drug Administration Schedule
- Drug Interactions
- Humans
- Isoenzymes