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Article

In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes.

Clinical pharmacology and therapeutics - 1 May 2005

Gurley Bill J, Gardner Stephanie F, Hubbard Martha A, Williams D Keith, Gentry W Brooks, Khan Ikhlas A, Shah Amit

Abstract excerpt

OBJECTIVES: Phytochemical-mediated modulation of cytochrome P450 (CYP) activity may underlie many herb-drug interactions. Single-time point phenotypic metabolic ratios were used to determine whether long-term supplementation of goldenseal ( Hydrastis canadensis ), black cohosh ( Cimicifuga racemosa ), kava kava ( Piper methysticum ), or valerian ( Valeriana officinalis ) extracts affected CYP1A2, CYP2D6, CYP2E1,...

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PMID: 15900287
DOI: 10.1016/j.clpt.2005.01.009
PMCID: PMC1894911

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