Interaction between two probes used for phenotyping cytochromes P4501A2 (caffeine) and P4502E1 (chlorzoxazone) in humans.

doi:10.1097/00008571-199504000-00003

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Article

Interaction between two probes used for phenotyping cytochromes P4501A2 (caffeine) and P4502E1 (chlorzoxazone) in humans.

Pharmacogenetics - 1 Apr 1995

Berthou F, Goasduff T, Lucas D, Dréano Y, Le Bot M H, Ménez J F

Abstract excerpt

The first steps in the metabolism of caffeine and chlorzoxazone are primarily catalysed by CYP1A2 and CYP2E1, respectively. Accordingly, these compounds have been developed as metabolic probes for non-invasive phenotyping of these two P450s. Their specificities, however, have been shown to overla...

Topics

Adult
Caffeine
Chlorzoxazone
Cytochrome P-450 CYP1A2
Cytochrome P-450 CYP2E1
Cytochrome P-450 Enzyme System
Female
Humans
Kinetics
Male
Middle Aged
Oxidoreductases
Oxidoreductases, N-Demethylating
Phenotype

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