Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humans.

doi:10.1067/mcp.2002.126913

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Article

Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humans.

Clinical pharmacology and therapeutics - 1 Sept 2002

Gurley Bill J, Gardner Stephanie F, Hubbard Martha A, Williams D Keith, Gentry W Brooks, Cui Yanyan, Ang Catharina Y W

Abstract excerpt

OBJECTIVES: Phytochemical-mediated modulation of cytochrome P450 (CYP) activity may underlie many herb-drug interactions. Single-time point phenotypic metabolic ratios were used to determine whether long-term supplementation of St John's wort, garlic oil, Panax ginseng, and Ginkgo biloba affected CYP1A2, CYP2D6, CYP2E1, or CYP3A4 activity. METHODS: Twelve healthy volunteers (6 females) were randomly assigned to...

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PMID: 12235448
DOI: 10.1067/mcp.2002.126913

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.