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Article

Validation of incorporating flurbiprofen into the Pittsburgh cocktail.

Clinical pharmacology and therapeutics - 1 Sept 2006

Zgheib Nathalie K, Frye Reginald F, Tracy Timothy S, Romkes Marjorie, Branch Robert A

Abstract excerpt

BACKGROUND: We have previously shown that flurbiprofen metabolism to 4'-hydroxyflurbiprofen provides an in vivo measure of cytochrome P450 (CYP) 2C9 activity. This study evaluated the possibility of incorporating flurbiprofen into the current 5-drug Pittsburgh cocktail. METHODS: In a randomized, 3-way, Latin-square, crossover-design study, 24 healthy subjects (mean age [+/-SD], 47.8 +/- 15.1 years) received...

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Source

Identifiers

PMID: 16952492
DOI: 10.1016/j.clpt.2006.06.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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