Article
[Assessment of biotransformation capacity following oral administration of various model substances as cocktail].
Zeitschrift fur Gastroenterologie - 1 Dec 1991
Henschel L, Hoffmann A
Abstract excerpt
A cocktail of four model substances orally administered to humans is used for simultaneous characterization of phenobarbital and 3-methylcholanthrene inducible forms of cytochrome-P450 and two genetic polymorphisms, the debrisoquine hydroxylation and N-acetylation. The investigations offer the possibility to assess four main processes of hepatic drug metabolism as well as the judgement of alterations in drug...
Topics
- Acetylation
- Administration, Oral
- Adult
- Biotransformation
- Caffeine
- Cytochrome P-450 Enzyme System
- Debrisoquin
- Dipyrone
- Humans
- Hydroxylation
- Liver
- Male