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Article

[Assessment of biotransformation capacity following oral administration of various model substances as cocktail].

Zeitschrift fur Gastroenterologie - 1 Dec 1991

Henschel L, Hoffmann A

Abstract excerpt

A cocktail of four model substances orally administered to humans is used for simultaneous characterization of phenobarbital and 3-methylcholanthrene inducible forms of cytochrome-P450 and two genetic polymorphisms, the debrisoquine hydroxylation and N-acetylation. The investigations offer the possibility to assess four main processes of hepatic drug metabolism as well as the judgement of alterations in drug...

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PMID: 1771946

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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