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Article

Bioequivalence revisited: influence of age and sex on CYP enzymes.

Clinical pharmacology and therapeutics - 1 Dec 2004

Bebia Zourab, Buch Shama C, Wilson John W, Frye Reginald F, Romkes Marjorie, Cecchetti Alfred, Chaves-Gnecco Diego, Branch Robert A

Abstract excerpt

BACKGROUND AND OBJECTIVE: The activity of cytochrome P450 (CYP) enzymes, which determine the rate of elimination of lipid-soluble drugs, demonstrates considerable interindividual variability. The extent to which age and sex influence CYP activity remains unclear in humans. Our objectives were to determine whether in vivo activity of selected CYP enzymes is affected by age or sex and to evaluate sex bioequivalence...

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Identifiers

PMID: 15592333
DOI: 10.1016/j.clpt.2004.08.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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