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Article

How useful is the "cocktail approach" for evaluating human hepatic drug metabolizing capacity using cytochrome P450 phenotyping probes in vivo?

Journal of clinical pharmacy and therapeutics - 1 Jun 2003

Tanaka E, Kurata N, Yasuhara H

Abstract excerpt

Relatively selective in vivo substrate probes have been developed for several major CYP isoforms involved in oxidative drug metabolism. There are basically two in vivo methods for identifying the phenotype. One method, the selective (CYP-specific) phenotyping method, involves administering one single probe drug, whereas the other is a mixed phenotyping or "cocktail" method involving the simultaneous...

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PMID: 12795773
DOI: 10.1046/j.1365-2710.2003.00486.x

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