Article
Genealogy of the CCR5 locus and chemokine system gene variants associated with altered rates of HIV-1 disease progression.
Nature medicine - 1 Jul 1998
Mummidi S, Ahuja S S, Gonzalez E, Anderson S A, Santiago E N, Stephan K T, Craig F E, O'Connell P, Tryon V, Clark R A, Dolan M J, Ahuja S K
Abstract excerpt
Allelic variants for the HIV-1 co-receptors chemokine receptor 5 (CCR5) and CCR2, as well as the ligand for the co-receptor CXCR4, stromal-derived factor (SDF-1), have been associated with a delay in disease progression. We began this study to test whether polymorphisms in the CCR5 regulatory regions influence the course of HIV-1 disease, as well as to examine the role of the previously identified allelic...
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