Article
Causal pathways for CCR5 genotype and HIV progression.
Journal of acquired immune deficiency syndromes (1999) - 1 Feb 2000
Taylor J M, Wang Y, Ahdieh L, Chmiel J S, Detels R, Giorgi J V, Kaslow R, Kingsley L, Margolick J
Abstract excerpt
A homozygous 32-bp deletion in the gene encoding CCR5, a major coreceptor for HIV-1, leads to resistance to infection with HIV-1, and heterozygosity for the deletion is associated with delayed disease progression in persons infected with HIV-1. We investigated the effect of CCR5 heterozygosity on disease progression as measured by both CD4+ T-cell count decline and the occurrence of clinical AIDS symptoms. Using...
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