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Article

Insertional inactivation of the p53 gene during friend leukemia: a new strategy for identifying tumor suppressor genes.

The New biologist - 1 Nov 1990

Ben-David Y, Lavigueur A, Cheong G Y, Bernstein A

Abstract excerpt

Rearrangements within the p53 gene are observed in a high proportion of independent erythroleukemic cell lines derived from the spleens of mice infected with Friend leukemia virus. The majority of cells with at least one rearranged p53 allele do not express detectable levels of p53 protein. Here, we show that in 4 out of 19 newly established erythroleukemic cell lines induced by infecting DBA mice with either the...

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Identifiers

PMID: 2101628

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insertional inactivation of the p53 gene during friend leukemia: a new strategy for identifying tumor suppressor genes.PMID 2101628Read ↗

Inactivation of the cellular p53 gene is a common feature of Friend virus-induced erythroleukemia: relationship of inactivation to dominant transforming alleles.Semantic proximity Read ↗

Loss of p53 tumor suppressor function is required for in vivo progression of Friend erythroleukemia.Semantic proximity Read ↗

Friend virus induced murine erythroleukaemia: the p53 locus.Semantic proximity Read ↗

Pathogenesis of Friend leukemia virus.Semantic proximity Read ↗

Dissemination and tissue invasiveness in murine acute leukemia associated with acquisition of p53 mutation and loss of wild-type p53.Semantic proximity Read ↗

Frequent mutations in the p53 gene in human myeloid leukemia cell lines.Semantic proximity Read ↗

Frequent mutations in the p53 gene in human myeloid leukemia cell linesSemantic proximity Read ↗

Retroviral transduction of hematopoietic progenitor cells with mutant p53 promotes survival and proliferation, modifies differentiation potential and inhibits apoptosis.Semantic proximity Read ↗

Endogenous p53 regulation and function in early stage Friend virus-induced tumor progression differs from that following DNA damage.Semantic proximity Read ↗

Somatic inactivation of Tp53 in hematopoietic stem cells or thymocytes predisposes mice to thymic lymphomas with clonal translocations.Semantic proximity Read ↗

Spi-1 transgenic mice develop a clonal erythroleukemia which does not depend on p53 mutation.Semantic proximity Read ↗

A mouse erythroleukemia cell line possessing friend spleen focus-forming virus gp55 transgene and temperature-sensitive mutant p53 gene.Semantic proximity Read ↗

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