Article
Insertional inactivation of the p53 gene during friend leukemia: a new strategy for identifying tumor suppressor genes.
The New biologist - 1 Nov 1990
Ben-David Y, Lavigueur A, Cheong G Y, Bernstein A
Abstract excerpt
Rearrangements within the p53 gene are observed in a high proportion of independent erythroleukemic cell lines derived from the spleens of mice infected with Friend leukemia virus. The majority of cells with at least one rearranged p53 allele do not express detectable levels of p53 protein. Here,...
Topics
- Alleles
- Animals
- Base Sequence
- Cell Line
- Cell Transformation, Neoplastic
- Cell Transformation, Viral
- Friend murine leukemia virus
- Gene Expression Regulation, Neoplastic
- Gene Expression Regulation, Viral
- Genes, Dominant
- Genes, p53
- Leukemia, Erythroblastic, Acute
- Mice
- Mice, Inbred DBA
- Molecular Sequence Data
- Mutagenesis, Insertional
- Polycythemia
- Spleen Focus-Forming Viruses