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Article

Human parvovirus B19 DNA replication induces a DNA damage response that is dispensable for cell cycle arrest at phase G2/M.

Journal of virology - 1 Oct 2012

Lou Sai, Luo Yong, Cheng Fang, Huang Qinfeng, Shen Weiran, Kleiboeker Steve, Tisdale John F, Liu Zhengwen, Qiu Jianming

Abstract excerpt

Human parvovirus B19 (B19V) infection is highly restricted to human erythroid progenitor cells, in which it induces a DNA damage response (DDR). The DDR signaling is mainly mediated by the ATR (ataxia telangiectasia-mutated and Rad3-related) pathway, which promotes replication of the viral genome; however, the exact mechanisms employed by B19V to take advantage of the DDR for virus replication remain unclear. In...

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Identifiers

PMID: 22837195
DOI: 10.1128/JVI.01007-12
PMCID: PMC3457271

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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