Article
Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos.
Molecular cell - 1 Sept 1998
Tsai K Y, Hu Y, Macleod K F, Crowley D, Yamasaki L, Jacks T
Abstract excerpt
Mice mutant for the Rb tumor suppressor gene die in mid-gestation with defects in erythropoiesis, cell cycle control, and apoptosis. We show here that embryos mutant for both Rb and its downstream target E2f-1 demonstrate significant suppression of apoptosis and S phase entry in certain tissues c...
Topics
- Animals
- Apoptosis
- Carrier Proteins
- Cell Cycle
- Cell Cycle Proteins
- Crosses, Genetic
- DNA-Binding Proteins
- E2F Transcription Factors
- E2F1 Transcription Factor
- Embryo, Mammalian
- Fetal Death
- Genes, Retinoblastoma
- Genotype
- In Situ Nick-End Labeling
- Lung
- Mice
- Mice, Inbred C57BL
- Mice, Inbred Strains