Article
Carcinomas of the renal pelvis associated with smoking and phenacetin abuse: p53 mutations and polymorphism of carcinogen-metabolising enzymes.
International journal of cancer - 23 Oct 1998
Bringuier P P, McCredie M, Sauter G, Bilous M, Stewart J, Mihatsch M J, Kleihues P, Ohgaki H
Abstract excerpt
Phenacetin abuse and smoking are established risk factors for transitional cell carcinomas of the urinary tract. In the present study, we analysed exposure and the clinical course of patients who underwent nephrectomy for transitional cell carcinoma of the renal pelvis. PCR-SSCP of archival, paraffin-embedded histological sections followed by direct DNA sequencing revealed that 29 of 89 (33%) renal pelvic...
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