Article
p53 mutations as fingerprints for aristolochic acid: an environmental carcinogen in endemic (Balkan) nephropathy.
Mutation research - 26 Apr 2009
Slade Neda, Moll Ute M, Brdar Branko, Zorić Arijana, Jelaković Bojan
Abstract excerpt
The activation of protooncogenes and inactivation of tumor suppressor genes are considered to be the main molecular events in the multistep process of carcinogenesis. Mutations of the TP53 tumor suppressor gene have been found in nearly all tumor types and are estimated to contribute to more than 50% of all cancers. Most mutations lead to the synthesis of highly stable, inactive proteins that accumulate in the...
Topics
- Aristolochic Acids
- Balkan Nephropathy
- Carcinogens, Environmental
- Humans
- Mutagens
- Mutation
- Tumor Suppressor Protein p53