Phenacetin acts as a weak genotoxic compound preferentially in the kidney of DNA repair deficient Xpa mice.

doi:10.1016/j.mrfmmm.2005.12.011

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Article

Phenacetin acts as a weak genotoxic compound preferentially in the kidney of DNA repair deficient Xpa mice.

Mutation research - 11 Apr 2006

Luijten Mirjam, Speksnijder Ewoud N, van Alphen Niels, Westerman Anja, Heisterkamp Siem H, van Benthem Jan, van Kreijl Coen F, Beems Rudolf B, van Steeg Harry

Abstract excerpt

Chronic use of phenacetin-containing analgesics has been associated with the development of renal cancer. To establish genotoxicity as a possible cause for the carcinogenic effect of phenacetin, we exposed wild type and DNA repair deficient Xpa-/- and Xpa-/-/Trp53+/- mice (further referred as Xpa and Xpa/p53 mice, respectively), carrying a reporter lacZ gene, to 0.75% (w/w) phenacetin mixed in feed. Xpa mice...

Topics

Animals
Carcinogens
Female
Kidney
Liver
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Mutagens
Mutation
Phenacetin
Sex Characteristics
Spleen
Tumor Suppressor Protein p53

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Identifiers

PMID: 16464479
DOI: 10.1016/j.mrfmmm.2005.12.011

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Xeroderma Pigmentosum Group A Protein