Article
TP53 Mutational signature for aristolochic acid: an environmental carcinogen.
International journal of cancer - 15 Sept 2011
Moriya Masaaki, Slade Neda, Brdar Branko, Medverec Zvonimir, Tomic Karla, Jelaković Bojan, Wu Lin, Truong Sim, Fernandes Andrea, Grollman Arthur P
Abstract excerpt
This study was designed to establish the TP53 mutational spectrum of aristolochic acid (AA), examined in the context of endemic (Balkan) nephropathy, an environmental disease associated with transitional cell (urothelial) carcinomas of the upper urinary tract (UUC). Tumor tissue was obtained from residents of regions in Bosnia, Croatia and Serbia where endemic nephropathy has been prevalent for over 50 years....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
