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Article

Influence of GSTM1, GSTT1, GSTP1 and NAT2 genotypes on the p53 mutational spectrum in bladder tumours.

International journal of cancer - 20 Feb 2005

Ryk Charlotta, Berggren Petra, Kumar Rajiv, Hemminki Kari, Larsson Per, Steineck Gunnar, Lambert Bo, Hou Sai-Mei

Abstract excerpt

Genetic polymorphisms affecting expression or activity of the corresponding enzymes can influence the risk of acquiring gene mutations and various cancers. We have studied 327 bladder cancer patients with regard to the functionally related polymorphisms of GSTM1, GSTT1, GSTP1 and NAT2 and analysed the p53 mutational status of their tumours. Fifty p53 mutations, 26% transversions and 74% transitions, were detected...

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Source

Identifiers

PMID: 15499621
DOI: 10.1002/ijc.20650

Genes

GSTM1
GSTP1
NAT2
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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