Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphic enzymes of xenobiotic metabolism as modulators of acquired P53 mutations in bladder cancer.

Pharmacogenetics - 1 Dec 1996

Brockmöller J, Kaiser R, Kerb R, Cascorbi I, Jaeger V, Roots I

Abstract excerpt

Occurrence or specific types of mutations found in oncogenes or tumor suppressor genes may partially be determined by activities of toxifying or detoxifying enzymes, such as glutathione S-transferases (GST) M1 and T1, arylamine N-acetyltransferase (NAT2), microsomal epoxide hydrolase, and the cytochrome P-450 enzymes 2D6, 1A1, 2A6, and 2E1. In an explorative observational study, 69 bladder cancer patients were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Cytochrome P-450 Enzyme System
Share to DNA Primers

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, p53

Share to Glutathione Transferase

Share to Mutation

Share to Polymerase Chain Reaction

Share to Polymorphism, Genetic

Source

Identifiers

PMID: 9014203
DOI: 10.1097/00008571-199612000-00007

Genes

NAT2
GSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphic enzymes of xenobiotic metabolism as modulators of acquired P53 mutations in bladder cancer.PMID 9014203Read ↗

Impact of polymorphisms in xeno(endo)biotic metabolism on pattern and frequency of p53 mutations in bladder cancer.Semantic proximity Read ↗

p53 mutations in bladder cancer: evidence for exogenous versus endogenous risk factors.Semantic proximity Read ↗

Combined analysis of inherited polymorphisms in arylamine N-acetyltransferase 2, glutathione S-transferases M1 and T1, microsomal epoxide hydrolase, and cytochrome P450 enzymes as modulators of bladder cancer risk.Semantic proximity Read ↗

Influence of GSTM1, GSTT1, GSTP1 and NAT2 genotypes on the p53 mutational spectrum in bladder tumours.Semantic proximity Read ↗

Markers of genetic susceptibility in human environmental hygiene and toxicology: the role of selected CYP, NAT and GST genes.Semantic proximity Read ↗

Genetic polymorphisms in human xenobiotica metabolizing enzymes as susceptibility factors in toxic response.Semantic proximity Read ↗

Variations in CYP isoforms and bladder cancer: a superfamily paradigm.Semantic proximity Read ↗

Gender-specific effects of NAT2 and GSTM1 in bladder cancer.Semantic proximity Read ↗

Polymorphisms of xenobiotic metabolizing enzymes in bladder cancer patients of the Semmelweis University Budapest, Hungary.Semantic proximity Read ↗

Genetic variability in susceptibility and response to toxicants.Semantic proximity Read ↗

Genotyping for polymorphisms in xenobiotic metabolism as a predictor of disease susceptibility.Semantic proximity Read ↗

Genetic susceptibility, biomarker respones, and cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.