Article
Polymorphic enzymes of xenobiotic metabolism as modulators of acquired P53 mutations in bladder cancer.
Pharmacogenetics - 1 Dec 1996
Brockmöller J, Kaiser R, Kerb R, Cascorbi I, Jaeger V, Roots I
Abstract excerpt
Occurrence or specific types of mutations found in oncogenes or tumor suppressor genes may partially be determined by activities of toxifying or detoxifying enzymes, such as glutathione S-transferases (GST) M1 and T1, arylamine N-acetyltransferase (NAT2), microsomal epoxide hydrolase, and the cyt...
Topics
- Arylamine N-Acetyltransferase
- Base Sequence
- Cytochrome P-450 Enzyme System
- DNA Primers
- Epoxide Hydrolases
- Genes, p53
- Glutathione Transferase
- Humans
- Inactivation, Metabolic
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Urinary Bladder Neoplasms
- Xenobiotics