Tyrosine phosphorylation of focal adhesion kinase stimulated by hepatocyte growth factor leads to mitogen-activated protein kinase activation.

doi:10.1074/jbc.273.40.25777

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Article

Tyrosine phosphorylation of focal adhesion kinase stimulated by hepatocyte growth factor leads to mitogen-activated protein kinase activation.

The Journal of biological chemistry - 2 Oct 1998

Chen H C, Chan P C, Tang M J, Cheng C H, Chang T J

Abstract excerpt

Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase involved in integrin-mediated signal transduction pathway. In this report, we describe that the treatment of hepatocyte growth factor (HGF) stimulates a significant increase in the tyrosine phosphorylation of FAK in human embryonic kidn...

Topics

Adaptor Proteins, Signal Transducing
Binding Sites
Calcium-Calmodulin-Dependent Protein Kinases
Cell Adhesion
Cell Adhesion Molecules
Cell Line
Cytochalasin D
Enzyme Activation
Epitopes
Focal Adhesion Kinase 1
Focal Adhesion Protein-Tyrosine Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

GRB2 Adaptor Protein

Genes, ras

Hemagglutinins

Hepatocyte Growth Factor

Humans

Infant, Newborn

Mutation

Source

Open in PubMed

Identifiers

PMID: 9748249
DOI: 10.1074/jbc.273.40.25777

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9748249-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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