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Article

Src phosphorylates Grb2-associated binder 1 upon hepatocyte growth factor stimulation.

The Journal of biological chemistry - 7 Nov 2003

Chan Po-Chao, Chen Yen-Ling, Cheng Chi-Hung, Yu Kuo-Ching, Cary Leslie A, Shu Kuo-Hsiung, Ho William L, Chen Hong-Chen

Abstract excerpt

Grb2-associated binder 1 (Gab1) is known to play an important role in hepatocyte growth factor (HGF) signaling, which rapidly becomes tyrosine-phosphorylated upon HGF stimulation. In this study, we found that the tyrosine phosphorylation of Gab1 in the cells derived from Src/Yes/Fyn null mouse embryos was approximately 40% lower than that in their wild type counterparts upon HGF stimulation. Increased expression...

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Source

Identifiers

PMID: 12941962
DOI: 10.1074/jbc.M305745200

Genes

HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Src phosphorylates Grb2-associated binder 1 upon hepatocyte growth factor stimulation.PMID 12941962Read ↗

Up-regulation of Grb2-associated binder 1 promotes hepatocyte growth factor induced endothelial progenitor cell proliferation and migrationSemantic proximity Read ↗

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G-CSF-induced tyrosine phosphorylation of Gab2 is Lyn kinase dependent and associated with enhanced Akt and differentiative, not proliferative, responses.Semantic proximity Read ↗

Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor.Semantic proximity Read ↗

Membrane targeting of Grb2-associated binder-1 (Gab1) scaffolding protein through Src myristoylation sequence substitutes for Gab1 pleckstrin homology domain and switches an epidermal growth factor response to an invasive morphogenic program.Semantic proximity Read ↗

Participation of both Gab1 and Gab2 in the activation of the ERK/MAPK pathway by epidermal growth factor.Semantic proximity Read ↗

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