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Article

c-Src kinase activity is required for hepatocyte growth factor-induced motility and anchorage-independent growth of mammary carcinoma cells.

The Journal of biological chemistry - 11 Dec 1998

Rahimi N, Hung W, Tremblay E, Saulnier R, Elliott B

Abstract excerpt

Overexpression and amplification of hepatocyte growth factor (HGF) receptor (Met) have been detected in many types of human cancers, suggesting a critical role for Met in growth and development of malignant cells. However, the molecular mechanism by which Met contributes to tumorigenesis is not well known. The tyrosine kinase c-Src has been implicated as a modulator of cell proliferation, spreading, and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9837958
DOI: 10.1074/jbc.273.50.33714

Genes

HGF
SRC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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c-Src kinase activity is required for hepatocyte growth factor-induced motility and anchorage-independent growth of mammary carcinoma cells.PMID 9837958Read ↗

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c-Met as a target for human cancer and characterization of inhibitors for therapeutic intervention.Semantic proximity Read ↗

Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cellsSemantic proximity Read ↗

Activation of c-Src by receptor tyrosine kinases in human colon cancer cells with high metastatic potential.Semantic proximity Read ↗

c-Met: structure, functions and potential for therapeutic inhibition.Semantic proximity Read ↗

MET: a critical player in tumorigenesis and therapeutic target.Semantic proximity Read ↗

The roles of hepatocyte growth factor/scatter factor and met receptor in human cancers (Review).Semantic proximity Read ↗

Src family kinases, adaptor proteins and the actin cytoskeleton in epithelial-to-mesenchymal transitionSemantic proximity Read ↗

Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions.Semantic proximity Read ↗

Expression and mutational analysis of MET in human solid cancers.Semantic proximity Read ↗

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