Article
A novel activating function of c-Src and Stat3 on HGF transcription in mammary carcinoma cells.
Oncogene - 4 May 2006
Wojcik E J, Sharifpoor S, Miller N A, Wright T G, Watering R, Tremblay E A, Swan K, Mueller C R, Elliott B E
Abstract excerpt
In the normal breast, hepatocyte growth factor (HGF) is primarily expressed by stromal cells, and stimulates in a paracrine manner epithelial cells expressing the HGF receptor (Met). In invasive human breast carcinomas, HGF and Met are frequently overexpressed, possibly establishing an autocrine HGF/Met loop that promotes tumour cell invasion. However, the mechanisms leading to autocrine HGF expression in...
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