Article
Major histocompatibility complex class II alleles and the course and outcome of MS: a population-based study.
Neurology - 1 Sept 1998
Weinshenker B G, Santrach P, Bissonet A S, McDonnell S K, Schaid D, Moore S B, Rodriguez M
Abstract excerpt
BACKGROUND: The major histocompatibility complex (MHC) has been consistently associated with susceptibility to MS and the course of several other human autoimmune diseases. A putative association between the course and severity of MS and the MHC remains controversial. METHODS: DR and DQ genotypin...
Topics
- Adult
- Alleles
- Cross-Sectional Studies
- Disease Susceptibility
- Female
- Genes, MHC Class II
- Genotype
- HLA-DQ Antigens
- HLA-DR Antigens
- Haplotypes
- Humans
- Male
- Minnesota
- Multiple Sclerosis
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Prognosis