Article
HLA genotype-clinical phenotype correlations in multiple sclerosis and neuromyelitis optica spectrum disorders based on Japan MS/NMOSD Biobank data.
Scientific reports - 12 Jan 2021
Watanabe Mitsuru, Nakamura Yuri, Sato Shinya, Niino Masaaki, Fukaura Hikoaki, Tanaka Masami, Ochi Hirofumi, Kanda Takashi, Takeshita Yukio, Yokota Takanori, Nishida Yoichiro, Matsui Makoto, Nagayama Shigemi, Kusunoki Susumu, Miyamoto Katsuichi, Mizuno Masanori, Kawachi Izumi, Saji Etsuji, Ohashi Takashi, Shimohama Shun, Hisahara Shin, Nishiyama Kazutoshi, Iizuka Takahiro, Nakatsuji Yuji, Okuno Tatsusada, Ochi Kazuhide, Suzumura Akio, Yamamoto Ken, Kawano Yuji, Tsuji Shoji, Hirata Makoto, Sakate Ryuichi, Kimura Tomonori, Shimizu Yuko, Nagaishi Akiko, Okada Kazumasa, Hayashi Fumie, Sakoda Ayako, Masaki Katsuhisa, Shinoda Koji, Isobe Noriko, Matsushita Takuya, Kira Jun-Ichi
Abstract excerpt
HLA genotype-clinical phenotype correlations are not established for multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD). We studied HLA-DRB1/DPB1 genotype-phenotype correlations in 528 MS and 165 NMOSD cases using Japan MS/NMOSD Biobank materials. HLA-DRB1*04:05, DRB1*15:01 and DPB1*03:01 correlated with MS susceptibility and DRB1*01:01, DRB1*09:01, DRB1*13:02 and DPB1*04:01 were...
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