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Article

Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing.

Molecular and cellular biology - 1 Apr 1995

Ren M, Villamarin A, Shih A, Coutavas E, Moore M S, LoCurcio M, Clarke V, Oppenheim J D, D'Eustachio P, Rush M G

Abstract excerpt

The small Ras-related GTP binding and hydrolyzing protein Ran has been implicated in a variety of processes, including cell cycle progression, DNA synthesis, RNA processing, and nuclear-cytosolic trafficking of both RNA and proteins. Like other small GTPases, Ran appears to function as a switch: Ran-GTP and Ran-GDP levels are regulated both by guanine nucleotide exchange factors and GTPase activating proteins,...

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Identifiers

PMID: 7891706
DOI: 10.1128/MCB.15.4.2117
PMCID: PMC230439

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