Article
RanGAP1 induces GTPase activity of nuclear Ras-related Ran.
Proceedings of the National Academy of Sciences of the United States of America - 29 Mar 1994
Bischoff F R, Klebe C, Kretschmer J, Wittinghofer A, Ponstingl H
Abstract excerpt
The nuclear Ras-related protein Ran binds guanine nucleotide and is involved in cell cycle regulation. Models of the signal pathway predict Ran to be active as Ran.GTP at the initiation of S phase upon activation by the nucleotide exchange factor RCC1 and to be inactivated for the onset of mitosi...
Topics
- Cell Compartmentation
- Enzyme Induction
- GTP Phosphohydrolases
- GTP-Binding Proteins
- GTPase-Activating Proteins
- HeLa Cells
- Humans
- Molecular Weight
- Mutation
- Nuclear Proteins
- Proteins
- Signal Transduction
- Substrate Specificity
- ran GTP-Binding Protein
- ras GTPase-Activating Proteins