Article
Mutations in a bacterial mechanosensitive channel change the cellular response to osmotic stress.
The Journal of biological chemistry - 19 Dec 1997
Blount P, Schroeder M J, Kung C
Abstract excerpt
MscL is a channel found in bacterial plasma membranes that opens a large pore in response to mechanical stress. Here we demonstrate that some mutations within this channel protein (K31D and K31E) evoke a cellular phenotype in which the growth rate is severely depressed. Increasing the osmolarity...
Topics
- Bacteria
- Bacterial Proteins
- Culture Media
- Escherichia coli Proteins
- Ion Channel Gating
- Ion Channels
- Ion Transport
- Mutation
- Osmotic Pressure
- Patch-Clamp Techniques
- Phenotype
- Potassium
- Stress, Mechanical