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Article

Mutations in a bacterial mechanosensitive channel change the cellular response to osmotic stress.

The Journal of biological chemistry - 19 Dec 1997

Blount P, Schroeder M J, Kung C

Abstract excerpt

MscL is a channel found in bacterial plasma membranes that opens a large pore in response to mechanical stress. Here we demonstrate that some mutations within this channel protein (K31D and K31E) evoke a cellular phenotype in which the growth rate is severely depressed. Increasing the osmolarity of the growth medium partially rescues this "slowed growth" phenotype and decreases an abnormal cytosolic potassium...

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Source

Identifiers

PMID: 9405414
DOI: 10.1074/jbc.272.51.32150

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mutations in a bacterial mechanosensitive channel change the cellular response to osmotic stress.PMID 9405414Read ↗

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Ionic regulation of MscK, a mechanosensitive channel from Escherichia coli.Semantic proximity Read ↗

A high-throughput screen for MscL channel activity and mutational phenotyping.Semantic proximity Read ↗

Charged pore-lining residues are required for normal channel kinetics in the eukaryotic mechanosensitive ion channel MSL1.Semantic proximity Read ↗

Characterization of three novel mechanosensitive channel activities in Escherichia coli.Semantic proximity Read ↗

Hydrophilicity of a single residue within MscL correlates with increased channel mechanosensitivity.Semantic proximity Read ↗

Mutations in a Conserved Domain of E. coli MscS to the Most Conserved Superfamily Residue Leads to Kinetic Changes.Semantic proximity Read ↗

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