Article
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.
Science (New York, N.Y.) - 11 Sept 1998
Canman C E, Lim D S, Cimprich K A, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan M B, Siliciano J D
Abstract excerpt
The p53 tumor suppressor protein is activated and phosphorylated on serine-15 in response to various DNA damaging agents. The gene product mutated in ataxia telangiectasia, ATM, acts upstream of p53 in a signal transduction pathway initiated by ionizing radiation. Immunoprecipitated ATM had intri...
Topics
- Ataxia Telangiectasia Mutated Proteins
- Cell Cycle Proteins
- Cell Line
- DNA Damage
- DNA-Activated Protein Kinase
- DNA-Binding Proteins
- Enzyme Activation
- Humans
- Lymphocytes
- Mutation
- Nuclear Proteins
- Phosphatidylinositol 3-Kinases
- Phosphorylation
- Phosphoserine
- Protein Kinases