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Article

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.

Science (New York, N.Y.) - 11 Sept 1998

Canman C E, Lim D S, Cimprich K A, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan M B, Siliciano J D

Abstract excerpt

The p53 tumor suppressor protein is activated and phosphorylated on serine-15 in response to various DNA damaging agents. The gene product mutated in ataxia telangiectasia, ATM, acts upstream of p53 in a signal transduction pathway initiated by ionizing radiation. Immunoprecipitated ATM had intrinsic protein kinase activity and phosphorylated p53 on serine-15 in a manganese-dependent manner. Ionizing radiation,...

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Source

Identifiers

PMID: 9733515
DOI: 10.1126/science.281.5383.1677

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.PMID 9733515Read ↗

Enhanced phosphorylation of p53 by ATM in response to DNA damage.Semantic proximity Read ↗

Activation of p53 transcriptional activity requires ATM's kinase domain and multiple N-terminal serine residues of p53.Semantic proximity Read ↗

A role for ATR in the DNA damage-induced phosphorylation of p53.Semantic proximity Read ↗

ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation.Semantic proximity Read ↗

Involvement of novel autophosphorylation sites in ATM activation.Semantic proximity Read ↗

Impaired genomic stability and increased oxidative stress exacerbate different features of Ataxia-telangiectasia.Semantic proximity Read ↗

Hypoxia Links ATR and p53 through Replication ArrestSemantic proximity Read ↗

Mutant p53 is constitutively phosphorylated at Serine 15 in UV-induced mouse skin tumors: involvement of ERK1/2 MAP kinase.Semantic proximity Read ↗

Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway.Semantic proximity Read ↗

p53 localization at centrosomes during mitosis and postmitotic checkpoint are ATM-dependent and require serine 15 phosphorylation.Semantic proximity Read ↗

[Interaction between ATM and radiation-activated phosphorylation of P53 and P21].Semantic proximity Read ↗

Dissecting the role of p53 phosphorylation in homologous recombination provides new clues for gain-of-function mutants.Semantic proximity Read ↗

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