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Article

Involvement of novel autophosphorylation sites in ATM activation.

The EMBO journal - 9 Aug 2006

Kozlov Sergei V, Graham Mark E, Peng Cheng, Chen Philip, Robinson Phillip J, Lavin Martin F

Abstract excerpt

ATM kinase plays a central role in signaling DNA double-strand breaks to cell cycle checkpoints and to the DNA repair machinery. Although the exact mechanism of ATM activation remains unknown, efficient activation requires the Mre11 complex, autophosphorylation on S1981 and the involvement of protein phosphatases and acetylases. We report here the identification of several additional phosphorylation sites on ATM...

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Identifiers

PMID: 16858402
DOI: 10.1038/sj.emboj.7601231
PMCID: PMC1538573

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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