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Article

Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation.

Genes & development - 1 Feb 2004

Ali Ambereen, Zhang Ji, Bao Shideng, Liu Irene, Otterness Diane, Dean Nicholas M, Abraham Robert T, Wang Xiao-Fan

Abstract excerpt

The checkpoint kinase ATM is centrally involved in the cellular response to DNA double-strand breaks. However, the mechanism of ATM activation during genotoxic stress is only partially understood. Here we report a direct regulatory linkage between the protein serine-threonine phosphatase 5 (PP5) and ATM. PP5 interacts with ATM in a DNA-damage-inducible manner. Reduced expression of PP5 attenuated...

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Source

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Identifiers

PMID: 14871926
DOI: 10.1101/gad.1176004
PMCID: PMC338278

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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