Mutations of the p53 gene in the stool of patients with resectable colorectal cancer.

doi:10.1002/(SICI)1097-0142(19960415)77:8<1707::AID-CNCR43>3.0.CO;2-0

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Article

Mutations of the p53 gene in the stool of patients with resectable colorectal cancer.

Cancer - 15 Apr 1996

Eguchi S, Kohara N, Komuta K, Kanematsu T

Abstract excerpt

BACKGROUND: This study was undertaken to evaluate whether genetic analysis in the stool can be useful for detecting malignant tumors in the colon and rectum. We searched for the possible presence of mutations in the p53 gene in the stool of patients with resectable colorectal cancer. Alterations in the p53 gene are the most frequent among mutant genes related to colorectal cancer. METHODS: Surgically resected...

Topics

Adult
Aged
Aged, 80 and over
Base Sequence
Colorectal Neoplasms
DNA, Neoplasm
Exons
Feces
Female
Genes, p53
Humans
Male
Middle Aged
Molecular Sequence Data
Mutation
Occult Blood
Polymerase Chain Reaction
Sensitivity and Specificity

Source

Open in PubMed

Identifiers

PMID: 8608566
DOI: 10.1002/(SICI)1097-0142(19960415)77:8<1707::AID-CNCR43>3.0.CO;2-0

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