Article
[p53 gene mutation in cancer of the colon and rectum].
Revista medica de Chile - 1 Sept 2000
Roa J C, Roa I, Melo A, Araya J C, Villaseca M A, Flores M, Schneider B
Abstract excerpt
BACKGROUND: Genetic events associated to colorectal carcinoma are well characterized, but there is scanty information about this issue in Chilean subjects. AIM: To determine the frequency and distribution of exons 5, 6, 7, 8 and 9 mutations and the immunohistochemical expression of p53 gene in biopsy samples of colorectal carcinoma. MATERIAL AND METHODS: p53 gene exons 5, 6, 7, 8 and 9 were directly sequenced in...
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